Cephalothin Synthesis Technology

Abstract

In 1948, Brotzu found that cephalosporium acremonium was secreted in the sea in the vicinity of the sewerage discharge on the shore of Sardinia and that cephalosporin N, cephalosporin P and cephalosporin C were produced therefrom. Based on this discovery, various semisynthetic cephalosporin products have been developed. Among these, cephalothin is a cephalosporin developed in initial stages and designed to be used for injection. Highly effective against both gram-positive and gram-negative bacteria, cephalothin is an extensive antibiotic which can be primarily administered to penicillin-sensitive patients and all other cases infected with various inflammations, with its effect widely known.