Abstract:
In 1948, Brotzu found that cephalosporium acremonium
was secreted in the sea in the vicinity of the
sewerage discharge on the shore of Sardinia and that
cephalosporin N, cephalosporin P and cephalosporin
C were produced therefrom.
Based on this discovery, various semisynthetic
cephalosporin products have been developed. Among
these, cephalothin is a cephalosporin developed in
initial stages and designed to be used for injection.
Highly effective against both gram-positive and
gram-negative bacteria, cephalothin is an extensive
antibiotic which can be primarily administered to
penicillin-sensitive patients and all other cases infected
with various inflammations, with its effect widely
known.